Prevention of Pregnancy Complications in Antiphospholipid Syndrome
نویسندگان
چکیده
منابع مشابه
Impact of the Antiphospholipid Syndrome on Complications during Pregnancy
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the appearance of antiphospholipid antibodies (APA) and at least one clinical manifestation like venous and arterial thrombosis or recurrent miscarriages and fetal loss in the second and third trimester. This most common acquired thrombophilia can also cause placental insufficiency, preeclampsia, intrauterine growth r...
متن کاملAntiphospholipid Syndrome in Pregnancy
The antiphospholipid syndrome (APS) is a multisystemic disease, characterized by venous or arterial thromboses, or certain obstetric complications, and the presence of antiphospholipid antibodies (APAs)(1-4). APAs are a heterogeneous group of autoantibodies that bind to negatively charged phospholipids, phospholipid-binding protein, or a combination of the two. Lupus anticoagulant (LA), anticar...
متن کاملAntiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus anticoagulant test, is associated with adverse pregnancy outcomes, such as fetal death, recurrent e...
متن کاملScreening for antiphospholipid antibodies in women with pregnancy complications.
We read with great interest the article by Bates et al 1 in an issue of CHEST (February 2012), in which the authors evaluate the evidence on the risk of pregnancy complications in women with thrombophilia. In this guideline article, the authors recommend screen ing for antiphospholipid antibodies in women with recurrent early pregnancy loss with a high level of evidence (Grade 1B). The antiphos...
متن کاملIdentification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis
In the antiphospholipid syndrome (APS), patients produce antiphospholipid antibodies (aPL) that promote thrombosis and adverse pregnancy outcomes. Current therapy with anticoagulation is only partially effective and associated with multiple complications. We previously discovered that aPL recognition of cell surface β2-glycoprotein I (β2-GPI) initiates apolipoprotein E receptor 2 (apoER2)-depen...
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ژورنال
عنوان ژورنال: Hämostaseologie
سال: 2020
ISSN: 0720-9355,2567-5761
DOI: 10.1055/a-1113-0689